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First Look

Sixteen presenters from Brigham and Women’s Hospital, Massachusetts General Hospital, Massachusetts Eye and Ear, and McLean Hospital will give 10-minute presentations highlighting their discoveries and insights that will disrupt the fields of CNS/brain health, oncology, and inflammation & immunology. This session is designed for investors, leaders, donors, entrepreneurs, investigators, and others who share a passion for identifying emerging high-impact technologies.

2022 Winners

The World Forum’s First Look sessions promote early stage innovations from across Mass General Brigham. Two of these presentations were selected with additional recognition for addressing unmet need, having clinical impact, scientific strength and collaboration opportunities. In 2022 the two First Look prizes were awarded to Anil Chandraker, MD, Medical Director of Kidney and Pancreas Transplantation, BWH; Associate Professor of Medicine, HMS and Anna Krichevsky, PhD, Associate Professor of Neurology, BWH, HMS.

A Novel Cellular Therapeutic Approach to Replacing Toxic Immunosuppressive Drugs in Kidney Transplantation

Anil Chandraker, MD

Medical Director of Kidney and Pancreas Transplantation, BWH; Associate Professor of Medicine, HMS

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Development of RNA-Targeting Therapies for Malignant Brain Tumors

Anna Krichevsky, PhD

Associate Professor of Neurology, BWH

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2022 Presenters

Microbiota-Informed Strategies to Combat Disease: Leveraging Human-Microbiota Molecular Mechanisms of Action in Therapeutic Applications

Lynn Bry, MD, PhD

Director, Massachusetts Host-Microbiome Center, BWH; Associate Professor of Pathology, HMS

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A Novel Cellular Therapeutic Approach to Replacing Toxic Immunosuppressive Drugs in Kidney Transplantation

Anil Chandraker, MD

Medical Director of Kidney and Pancreas Transplantation, BWH; Associate Professor of Medicine, HMS

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3D Human Blood-Brain-Barrier Organoids for Modeling Therapeutic Delivery to the CNS

Choi-Fong Cho, PhD

Assistant Professor of Neurosurgery, BWH

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Restoration of Hearing and Vision with Gene Therapy

David Corey, PhD

Bertarelli Professor of Translational Medical Science, Neurobiology, HMS

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Genetic Studies of the NCLs: A Window into New Therapeutic Strategies for the NCLs and Related Neurodegenerative Disorders

Susan Cotman, PhD

Assistant Professor, Center for Genomic Medicine, MGH; Assistant Professor of Neurology, HMS

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Overcoming Gene Therapy Development Barriers for Ultra-Rare Diseases

Yulia Grishchuk, PhD

Assistant Investigator, Center for Genomic Medicine, MGH; Assistant Professor of Neurology, HMS

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Precision Medicine for Dementia: Patient-Derived Stem Cell Models & Targeted Protein Degradation

Stephen Haggarty, PhD

Director, MassGeneral Chemical Neurobiology Laboratory, Center for Genomic Medicine, MGH; Associate Professor of Neurology, HMS

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cGMP Methodology and Clinical Trial Preparations for Cell Therapy using Autologous iPSCs for Parkinson’s Disease

Ole Isacson, MD, PhD

Director, Neuroregeneration Research Institute, McLean; Professor of Neurology & Neuroscience, HMS

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Programming Cell Therapies with Targeted Protein Degradation

Max Jan, MD, PhD

Assistant Professor, Center for Cancer Research, MGH

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Development of RNA-Targeting Therapies for Malignant Brain Tumors

Anna Krichevsky, PhD

Associate Professor of Neurology, BWH

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Antisense Oligonucleotides for Cancer Immunotherapy

Marco Mineo, PhD

Instructor in Neurosurgery, BWH

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yBOTs: Self-Tunable Engineered Yeast for Controlled Therapeutic Delivery

Francisco Quintana, PhD

Professor, Neurology, Ann Romney Center for Neurologic Diseases, BWH; Kuchroo Weiner Distinguished Professor of Neuroimmunology, HMS

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Gene Therapy for Tuberous Sclerosis Complex

Vijaya Ramesh, PhD

Co-Director, Neuroscience, Associate Geneticist in Neurology, MGH; Professor of Neurology, HMS

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Olfactory Ensheathing Glia: An Unconventional Cell for Cancer Gene/Cell Therapy

Bakhos Tannous, PhD

Director, Experimental Therapeutics Unit, Director, Viral Vector Core, MGH; Associate Professor of Neurology, HMS

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A New Hydrogel for Ocular Delivery

Michael Young, PhD

Director, Minda de Gunzburg Center for Retinal Regeneration, Associate Scientist, Schepens Eye Research Institute, Mass Eye and Ear; Associate Professor of Ophthalmology, Co-Director, Ocular Regenerative Medicine Institute, HMS

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An AAV-based Single Dose, Thermostable Vaccine Platform that Provides Durable Immunogenicity

Nerea Zabaleta, PhD

Principal Investigator, Grousbeck Gene Therapy Center, Mass Eye and Ear; Instructor in Ophthalmology, HMS

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